Insulin humulin instructions for use. Unwanted side effects include. Release form and conditions of appointment.
Intermediate-acting human insulin
Release form, composition and packaging
Suspension for subcutaneous injection
Excipients: metacresol - 1.6 mg, glycerol - 16 mg, phenol - 0.65 mg, protamine sulfate - 0.348 mg, sodium hydrogen phosphate heptahydrate - 3.78 mg, zinc oxide - q.s. to obtain Zn 2+ no more than 40 μg, water for injection - up to 1 ml, hydrochloric acid solution 10% - q.s. to pH 6.9-7.8, sodium hydroxide solution 10% - q.s. up to pH 6.9-7.8.
Terms and conditions of storage
In muscle and other tissues, insulin causes intracellular transport of glucose and amino acids, promotes anabolism, and inhibits protein catabolism. Therefore, it is more appropriate to examine glucose utilization curves when considering insulin activity. Individual variations in blood glucose response profiles depend on factors such as dose size, injection site, and physical activity of the patient. Toxicology: Carcinogenesis, Mutagenesis, Impairment of Fertility: Human insulin is produced by recombinant technology.
3 ml - cartridges (5) - blisters (1) - cardboard pack.
3 ml - cartridge built into the QuickPen™ syringe pen (5) - cardboard pack.
Suspension for subcutaneous injection white color, which exfoliates, forming a white precipitate and a clear, colorless or almost colorless supernatant; the precipitate is easily resuspended with gentle shaking.
No serious events were reported in subchronic toxicology studies. Used in the treatment of diabetes. Information for counseling patients. For this reason, you should always use the syringe labeled with the strength of the insulin you are injecting. Using a Syringe: Follow these instructions exactly to avoid contamination and possible infection. Disposable syringes and needles should only be used once and then discarded. Syringes and reusable needles must be sterilized before each injection.
Dosage and administration
Follow the packaging instructions that came with the syringe. Described as follows: 2 sterilization methods. Insert: Place the syringe, plunger and needle into the strainer, place in a saucepan and cover with water. When they are cool, insert the plunger into the barrel and secure the needle with the syringe with a slight twist. Isolated alcohol: If the syringe, plunger, and needle cannot be boiled, they can be sterilized when you travel by dipping for at least 5 minutes in 91% isopropyl alcohol. Do not use bath, friction, or medicinal alcohol for this sterilization.
Excipients: metacresol - 1.6 mg, glycerol (glycerol) - 16 mg, phenol - 0.65 mg, protamine sulfate - 0.348 mg, sodium hydrogen phosphate heptahydrate - 3.78 mg, zinc oxide - q.s. to obtain Zn 2+ no more than 40 μg, water for injection - up to 1 ml, hydrochloric acid solution 10% - q.s. to pH 6.9-7.8, sodium hydroxide solution 10% - q.s. up to pH 6.9-7.8.
If the syringe is sterilized with alcohol, it must be completely dry before use. Dose preparation: Wash your hands. Thoroughly shake or swirl the insulin flask several times to completely mix the insulin. Do not use if it appears cloudy, thickened, or slightly colored, or if particulate matter is visible. Do not use it if you notice something unusual in appearance. If you are using a new bottle, flip off the plastic protective cap, but do not remove the stopper. When using a new bottle, wipe upper part bottles of alcohol smear.
Suspension for subcutaneous injection white, which stratifies, forming a white precipitate and a clear colorless or almost colorless supernatant; the precipitate is easily resuspended with gentle shaking.
Excipients: metacresol, glycerol, phenol, protamine sulfate, sodium hydrogen phosphate, zinc oxide, water for injection, hydrochloric acid 10% and sodium hydroxide solution 10% (to create the required pH level).
Draw air into the syringe equal to your dose of insulin. Place the needle through the rubber top of the insulin bottle and force air into the bottle. Turn the bottle and syringe upside down. Hold the bottle and syringe firmly in 1 hand. After making sure that the tip of the needle is in the insulin, withdraw the correct dose of insulin into the syringe. Before removing the needle from the bottle, check the syringe for air bubbles that reduce the amount of insulin in it. Push them out with a piston and take the correct dose. Draw air into the syringe equal to the amount of insulin over long-acting that the patient is taking.
4 ml - bottles (1) - packs of cardboard.
10 ml - bottles (1) - packs of cardboard.
pharmachologic effect
DNA recombinant human insulin. It is an intermediate-acting insulin preparation.
The main action of the drug is the regulation of glucose metabolism. In addition, it has an anabolic effect. In muscle and other tissues (with the exception of the brain), insulin causes rapid intracellular transport of glucose and amino acids, and accelerates protein anabolism. Insulin promotes the conversion of glucose to glycogen in the liver, inhibits gluconeogenesis, and stimulates the conversion of excess glucose into fat.
Now inject air into your regular human insulin bottle in the same way, but do not remove the needle. After making sure that the tip of the needle is in the insulin, withdraw the correct dose of regular insulin into the syringe needle. Stabilize the skin by spreading it or pinching a large area. Insert the needle as directed by the doctor. Press the piston all the way. It is important to read, understand, and follow the instructions for use for the specific roll of insulin you are using. Before inserting it into the pen, inspect the cartridge to make sure the contents appear clear and colorless.
Pharmacokinetics
Humulin NPH is an intermediate-acting insulin preparation.
The onset of action of the drug is 1 hour after administration, the maximum effect of action is between 2 and 8 hours, the duration of action is 18-20 hours.
Individual differences in insulin activity depend on factors such as dose, choice of injection site, physical activity of the patient.
Examine the appearance of the insulin cartridge after being removed from the box. Turn the cartridge over between your palms 10 times. Holding the cartridge by one end, rotate it 180º slowly 10 times to allow the glass bead to travel the full length of the cartridge with each inversion. Before inserting it into the pen, inspect the cartridge to make sure the contents appear uniformly cloudy or milky. If not, repeat the above steps until the content is mixed. Follow the pen manufacturer's instructions to load the cartridge into the pen and use the insulin pen.
Indications
- diabetes mellitus in the presence of indications for insulin therapy;
- newly diagnosed diabetes mellitus;
- pregnancy with diabetes mellitus type 2 (non-insulin dependent).
Contraindications
- hypoglycemia;
— hypersensitivity to insulin or to one of the components of the drug.
Dosage
The dose is set by the doctor individually, depending on the level of glycemia.
Dose administration: Wash your hands. Holding the pen at one end, slowly rotate it 180º 10 times to allow the glass bead to travel the full length of the cartridge with each inversion. directions for attaching the needle and changing the needle. Insulin cartridges may contain an air bubble that must be removed from the cartridge and needle by proper priming prior to injection. To avoid tissue damage, select a site for each injection that is at least 2 cm from the previous site.
With 1 hand, stabilize the skin by spreading it or pinching a large area. To administer insulin, follow the pen manufacturer's instructions. After dispensing a dose, withdraw the needle and apply gentle pressure to the injection site for a few seconds. Immediately after injection, remove the needle from the pen, which will ensure sterility and prevent leakage, re-entry of air and potential clogged needles. Dispose of the needle responsibly. Once a cartridge has been used, do not continue to use it if the leading edge of the plunger is at or past the last mark on the cartridge.
The drug should be administered subcutaneously, possibly intramuscularly. In / in the introduction of Humulin NPH is contraindicated!
Subcutaneously, the drug is injected into the shoulder, thigh, buttocks or abdomen. The injection site must be rotated so that the same site is used no more than about 1 time / month.
When s / c administration, care must be taken to avoid getting into a blood vessel. After the injection, do not massage the injection site. Patients should be taught the correct use of insulin delivery devices.
Indications, contraindications and side effects
Use the gauge on the side of the cartridge to help you judge how much insulin is left. It can be caused by: Taking too much insulin, exercising or working more than usual. Infection or disease. Need for insulin. mild symptoms and mild hypoglycemia may occur suddenly and may include: Sweating, dizziness, palpitations, tremors, hunger, restlessness, tingling in the arms, legs, lips, or tongue, light head, inability to concentrate, headache, drowsiness, sleep disturbance, anxiety, blurred vision , slurred speech, depressed mood, irritability, abnormal behavior, unsteady movement, personality changes.
Rules for the preparation and administration of the drug
Cartridges and vials of Humulin NPH should be rolled between the palms 10 times before use and shaken, turning 180 ° also 10 times to resuspend the insulin until it becomes a homogeneous cloudy liquid or milk. Do not shake vigorously as this may result in foaming which may interfere with correct dose retrieval.
Early symptoms hypoglycemia may be variable or less pronounced under certain conditions such as long-term diabetes, diabetic nerve disease, medications such as beta-blockers, changes in insulin preparations, or increased control of diabetes. Patients should always have a quick source of sugar, such as mints or glucose tablets. The patient must learn to recognize their own symptoms of hypoglycemia. If you are unsure about these symptoms, check your blood glucose frequently to recognize the symptoms you experience with hypoglycemia.
Cartridges and vials should be carefully checked. Do not use insulin if there are flakes in it after mixing, if solid white particles have stuck to the bottom or walls of the vial, creating the effect of a frosty pattern.
The design of the cartridges does not allow mixing their contents with other insulins directly in the cartridge itself. Cartridges are not designed to be refilled.
Eating significantly more than the meal plan suggests. In patients with insulin-dependent diabetes, prolonged hyperglycemia can lead to diabetic acidosis. The first symptoms of diabetic acidosis usually come on gradually, over hours or days, and include a feeling of sleepiness, a flushed face, thirst, loss of appetite, and a fruity breath. In acidosis, urine tests show a large amount of glucose and acetone. If not corrected, prolonged hyperglycemia or diabetic acidosis can lead to nausea, vomiting, dehydration, unconsciousness, or death.
The contents of the vial should be drawn into insulin syringe corresponding to the concentration of insulin being administered, and inject the desired dose of insulin as directed by the physician.
When using cartridges, follow the manufacturer's instructions for refilling the cartridge and attaching the needle. The drug should be administered in accordance with the instructions of the manufacturer of the syringe pen.
Therefore, it is important to get medical help immediately. Additional information can be obtained from a doctor or pharmacist. Lipodystrophy. If any of these conditions are noticed, see your doctor. Changing the injection method may help alleviate the problem. Interaction with insulin: local allergy. Patients sometimes experience redness, swelling, and itching at the site of the insulin injection. If there are local reactions, consult a doctor. Systemic allergy: less common, but potentially more serious, is a generalized allergy to insulin that can cause a rash all over the body, shortness of breath, wheezing, decreased blood pressure, fast pulse or sweating.
Using the outer needle cap, unscrew the needle immediately after insertion and safely dispose of it. Removing the needle immediately after injection ensures sterility and prevents leakage, air entry and possible clogging of the needle. Then put the cap on the pen.
Needles should not be reused. Needles and pens should not be used by others. Cartridges and vials are used until they are empty, after which they should be discarded.
About the composition and form of release
If you have a generalized allergic reaction on insulin, tell your doctor immediately. Always be sure to wipe the skin with alcohol ointment and let it dry. Buttocks Buttocks Upper legs Upper arms. . Timing is important to help reduce your risk of low blood sugar, so be sure to plan your meals ahead of time. Of course, if you have any questions, be sure to talk to your doctor. An unopened pen or vial should be stored in the refrigerator and discarded after the expiration date printed on the label.
Humulin NPH can be administered in combination with Humulin Regular. To do this, short-acting insulin should be drawn into the syringe first to prevent longer-acting insulin from entering the vial. It is desirable to introduce the prepared mixture immediately after mixing. A separate syringe for Humulin Regular and Humulin NPH can be used to administer the exact amount of each type of insulin.
Do not freeze or use previously frozen insulin. Do not use if it has been frozen. An unopened vial should be stored in the refrigerator until the expiration date. An opened vial can be stored at room temperature and discarded within 40 days of opening, even if insulin remains.
You can give other people a serious infection or get a serious infection from them. Tell your doctor if you have liver, kidney or heart problems or any other medical conditions. About all medications you take, including prescription and over-the-counter medications, vitamins, and herbal supplements. Check your insulin label each time you inject to make sure you are using the correct insulin. The markings on certain syringes will not measure your dose correctly. Severe overdose can occur, causing low blood sugar, which can put your life in danger. This can cause your blood sugar levels to be too low or too high level blood sugar. Do not drink alcohol or use medicines that contain alcohol. Signs of low blood sugar may include dizziness or dizziness, sweating, confusion, headache, blurred vision, slurred speech, trembling, fast heartbeat, restlessness, irritability or mood changes or hunger. Your supplier medical services may prescribe a glucagon delivery kit so others can give you an injection if your blood sugar gets too low and you can't take the sugar in your mouth. Contact immediately medical care if you have a rash all over your body, have trouble breathing, a fast heart, or sweating. This can happen even if you have never had heart failure or heart problems. Tell your doctor if you have any new or worse symptoms of heart failure, including shortness of breath, swelling of your ankles or legs, or sudden weight gain. Serious low blood sugar requiring hospitalization or emergency care. Throw away any opened vial after 40 days of use, even if there is insulin in the vial. Medications are sometimes prescribed for purposes other than those listed on the Patient Information Sheet. If you need more information, talk to your health care provider. Hyperglycemia, hypoglycemia, or death due to dosing errors in vial presentation. Instruct patients to always check their insulin vials to confirm that the correct insulin is being dispensed, including the correct brand and strength. Changes in insulin, manufacturer, type or method of administration should be made carefully and only under medical supervision, and the frequency of blood glucose monitoring should be increased. Hypoglycemia may impair concentration ability and reaction time; This can put the individual and others at risk in situations where these abilities are important, such as driving or operating other machinery. Hypoglycemia can happen suddenly, and symptoms can vary from person to person and change over time in the same person. Early symptoms of hypoglycemia may be less pronounced in patients with longstanding diabetes, in patients with diabetic nervous disease, in patients using drugs that block sympathetic nervous system, or in patients with recurrent hypoglycemia. The time of hypoglycemia generally reflects the time action profile of the insulin formulation administered. Patients and caregivers should be educated to recognize and manage hypoglycemia. Self-monitoring of blood glucose plays an important role in the prevention and treatment of hypoglycemia. In patients at increased risk of developing hypoglycemia and in patients who experience a reduction in symptomatic symptoms of hypoglycemia, it is recommended to increase the frequency of blood glucose monitoring. Hypokalemia: The use of insulin can lead to hypokalemia that is left untreated, can cause respiratory paralysis, ventricular arrhythmias, and death. Adverse reactions include hypoglycemia, allergic reactions, lipodystrophy, injection site reactions, weight gain, peripheral edema, and immunogenicity. Some medicines can change glucose metabolism and may require an adjustment in the insulin dose. Signs of hypoglycemia may be reduced or absent in patients taking antiadrenergic drugs. In elderly diabetic patients, the initial dose, dose, and maintenance dose should be conservative to avoid hypoglycemia. Renal or hepatic insufficiency: Frequent monitoring of glucose and dose reduction of insulin may be required in patients with renal or hepatic insufficiency. Make sure the patient understands these instructions and can correctly draw the prescribed dose with their syringe. Advise patient to read patient information and instructions for use. Ask patients to always check the insulin label before administering to confirm that the correct insulin product is being used.
- If you are pregnant, planning to become pregnant, or breastfeeding.
- Do not change your dose unless you have been told by your healthcare provider.
- Severe allergic reaction.
- Keep away from sources of heat and direct light.
- Do not shake the vial.
- This may harm them.
- Ask patients to always check the insulin label before each injection.
- Follow administration instructions.
- Overdoses and severe hypoglycemia may occur.
- Exchange represents the risk of transmission of blood-borne pathogens.
- Hyperglycemia or hypoglycemia with changes in insulin regimen.
- Fluid retention may lead to or exacerbate heart failure.
- Monitor patients for signs and symptoms of heart failure.
- Close monitoring may be required.
- Each label represents 5 units of insulin.
Always use an insulin syringe that matches the concentration of insulin being administered.
Side effects
Side effect associated with the main action of the drug: hypoglycemia.
Severe hypoglycemia can lead to unconsciousness and (in exceptional cases) death.
Allergic reactions: local allergic reactions are possible - hyperemia, swelling or itching at the injection site (usually stop within a period of several days to several weeks); systemic allergic reactions (occur less often, but are more serious) - generalized itching, difficulty breathing, shortness of breath, lowering blood pressure, increased heart rate, increased sweating. Severe cases of systemic allergic reactions can be life-threatening.
Others: the likelihood of developing lipodystrophy is minimal.
Overdose
Symptoms: hypoglycemia, accompanied by lethargy, increased sweating, tachycardia, pallor of the skin, headache, trembling, vomiting, confusion.
Under certain conditions, such as long duration or intensive control diabetes symptoms of hypoglycemia may change.
Treatment: mild hypoglycemia can usually be treated with oral glucose (dextrose) or sugar. Adjustment of insulin dose, diet, or physical activity may be required.
Correction of moderate hypoglycemia can be carried out using intramuscular or subcutaneous administration of glucagon, followed by ingestion of carbohydrates.
Severe conditions of hypoglycemia, accompanied by coma, convulsions or neurological disorders, are stopped by intramuscular or subcutaneous administration of glucagon or intravenous administration of a concentrated glucose solution (dextrose). After the restoration of consciousness, the patient must be given food rich in carbohydrates in order to avoid the recurrence of hypoglycemia.
drug interaction
The hypoglycemic effect of Humulin NPH is reduced by oral contraceptives, corticosteroids, thyroid hormone preparations, thiazide diuretics, diazoxide, tricyclic antidepressants.
The hypoglycemic effect of Humulin NPH is enhanced by oral hypoglycemic drugs, salicylates (eg, acetylsalicylic acid), sulfonamides, MAO inhibitors, beta-blockers, ethanol and ethanol-containing drugs.
Beta-blockers, clonidine, reserpine may mask the manifestation of symptoms of hypoglycemia.
Pharmaceutical interaction
The effects that occur when human insulin is mixed with animal-derived insulin or human insulin produced by other manufacturers have not been studied.
special instructions
Transferring a patient to another type of insulin or to an insulin preparation with another trade name should be done under strict medical supervision. Changes in insulin activity, type (e.g. Regular, M3), species (porcine, human insulin, human insulin analogue) or method of production (DNA recombinant or animal insulin) may necessitate dose adjustments.
The need for dose adjustment may be required already at the first administration of a human insulin preparation after an animal insulin preparation, or gradually over several weeks or months after the transfer.
The need for insulin may decrease with insufficient function of the adrenal glands, pituitary gland or thyroid gland, with renal or hepatic insufficiency.
In some diseases or emotional stress, the need for insulin may increase.
Dose adjustments may also be required when increasing physical activity or when changing the usual diet.
Symptoms-harbingers of hypoglycemia on the background of the introduction of human insulin in some patients may be less pronounced or different from those that were observed in them against the background of the introduction of insulin of animal origin. When blood glucose levels are normalized, for example, as a result of intensive care insulin, all or some of the symptoms, precursors of hypoglycemia, may disappear, about which patients should be informed.
Symptoms-harbingers of hypoglycemia may change or be less pronounced with prolonged diabetes mellitus, diabetic neuropathy, or with the simultaneous use of beta-blockers.
In some cases, local allergic reactions may be caused by causes unrelated to the action of the drug, such as skin irritation with a cleansing agent or improper injection.
In rare cases of systemic allergic reactions, immediate treatment is required. Sometimes you may need to change insulin or desensitization.
Influence on the ability to drive vehicles and control mechanisms
During hypoglycemia, the patient's ability to concentrate may deteriorate and the speed of psychomotor reactions may decrease. This can be dangerous in situations in which these abilities are especially needed (driving a car or operating machinery). Patients should be advised to take precautions to avoid hypoglycemia while driving. This is particularly important in patients with mild or no warning signs of hypoglycemia or who have frequent hypoglycemia. In such cases, the doctor must assess the feasibility of driving a car by the patient.
Pregnancy and lactation
During pregnancy, it is especially important to maintain good glycemic control in patients with diabetes mellitus. During pregnancy, the need for insulin usually decreases in the first trimester and increases in the second and third trimesters.
In diabetic patients during lactation ( breastfeeding) may require adjustments in insulin dose, diet, or both.
In genetic toxicity studies in in vitro and in vivo series, human insulin was not mutagenic.
For impaired renal function
The need for insulin may decrease with kidney failure.
For impaired liver function
The need for insulin may decrease with liver failure.
Terms of dispensing from pharmacies
The drug is dispensed by prescription.
Terms and conditions of storage
The drug should be stored in a refrigerator at a temperature of 2 ° to 8 ° C, avoid freezing, protect from direct exposure to light. Shelf life - 2 years.
The drug in use in a vial or in a cartridge should be stored at room temperature (from 15 ° to 25 ° C) for no more than 28 days.
One ml of Insulin Humulin contains 100 IU human insulin. The active ingredients of the drug should be considered 30% soluble insulin and 70% insulin isophane. As additional components, elements such as distilled metacresol, phenol and some others are used. Indications for use, instructions and some other information deserve special attention.
All about the form of release of insulin
Humulin injection composition NPH insulin available as a suspension for subcutaneous injection. It is produced in bottles of 10 ml, as well as in cartridges of 1.5 and three ml, which are packed in boxes of five pieces. Cartridges are intended for use in Humapen and BD-Pen syringe pens. It should be taken into account that:
- the drug is able to have a hypoglycemic effect;
- Humulin belongs to the category of DNA recombinant formulations and is a biphasic suspension for injection. At the same time, it is characterized by an average duration of exposure;
- from the moment the drug is introduced, its pharmacological effectiveness will be noted after at least 30, but not more than 60 minutes;
- maximum exposure will last from two to 12 hours;
- the total duration of exposure will be from 18 to 24 hours.
What are the indications for use and side effects?
Side effects are diagnosed hypoglycemia, as well as an increased degree of susceptibility.
Quite often, during treatment with hormonal components, including Humulin NPH, the formation of hypoglycemia is identified. If it is characterized by an aggravated form, then it may well have a corresponding effect on hypoglycemic coma (aggravation and loss of consciousness), as well as lead to the death of the patient.
In some diabetics certain allergic reactions may be identified which will be associated with skin itching, swelling and redness directly in the area of application of the composition. Traditionally, such symptoms go away on their own after a number of days or even weeks after the start of the recovery course.
In some cases, the presented condition does not have any connection with the use of the hormonal component itself. It may be the result of external factors or an incorrect injection. In the most severe situations, an allergic reaction can provoke a threat to the life of a diabetic and require medical intervention as soon as possible. In certain situations, it may be necessary to replace the hormonal component or perform desensitization.
In the process of using insulin of animal origin, resistance, an increased degree of susceptibility to the drug, as well as lipodystrophy can form.
In the process of using Humulin NPH insulin, the likelihood of such critical consequences is practically zero.
How exactly to use insulin?
Humulin should not be administered intravenously. It is highly recommended to pay attention to the following:
- when prescribing a hormonal component, the dosage and mode of implementation should be selected exclusively by a specialist;
- this should be done on an individual basis for each specific patient, depending on the indicators of glycemia in the body;
- Humulin is used for subcutaneous injection, but it is also acceptable to use it intramuscularly;
- under the skin, the drug is introduced exclusively into the area of the peritoneum, thigh, shoulder or one of the buttocks;
- it is permissible to inject a hormonal component in the same place no more than once a month.
When carrying out the procedure, it is recommended to use the used injection devices exclusively correctly. In particular, it is not recommended to allow the penetration of the needle into the area blood vessels, do not massage the injection area after it has been carried out. In this regard, it will be very important to familiarize yourself with the rules on how exactly the composition is implemented.
How to administer the drug correctly?
In order to properly inject medicinal product, it is highly recommended to carry out some preliminary procedures first. First of all, the injection area is determined, the hands are washed well, and the indicated place is wiped with a napkin that has been soaked in alcohol. After that, it is strongly recommended to remove the protective cap from the needle of the syringe, tighten and fix the skin. Then a needle is inserted and the injection is carried out.
Next, the needle will need to be removed and within a few seconds, without rubbing, press the injection area with a napkin. Further, with the help of a protective outer cap, it will be necessary to unscrew the needle, remove it and re-put the cap on the syringe pen. It must also be understood that it is strongly not recommended to use the same needle twice in a row. The vial or cartridge should be used until completely empty, after which it is discarded. Pen syringes should be designed exclusively for the individual process of use in order to exclude the possibility of complications and negative reactions.
Is an overdose possible?
Humulin NPH like the rest medications in the presented category medications do not have a specific definition of overdose. This is due to the fact that the levels of glucose in the blood serum will depend on the difference during the day between the levels of glucose, the hormonal component and other metabolic conditions. Of course, an overdose of insulin can be characterized by a truly negative effect. It is highly recommended to pay attention to the following:
- hypoglycemia is formed as a result of a discrepancy between the ratio of insulin in the blood plasma and the energy costs of the food consumed;
- developing hypoglycemia is characterized by symptoms such as lethargy, tachycardia, vomiting, and excessive sweating;
- in certain situations, for example, with a significant duration of diabetes mellitus or its constant monitoring, the symptoms of developing hypoglycemia can be very different.
A mild form of hypoglycemia can be eliminated by using glucose or sugar. In certain situations, it may be necessary to adjust the amount of insulin, revise diet food or change of pace physical activity. In the future, to exclude the recurrence of hypoglycemia, the diabetic will have to eat food that is saturated with carbohydrates. A truly aggravated degree of hypoglycemia implies an emergency hospitalization.
What are the storage conditions and special instructions?
Humulin NPH can be purchased at a pharmacy only with a prescription from a treating specialist.
The drug is strongly recommended to be stored at temperatures from two to eight degrees. In this case, the hormonal component is unacceptable not only to freeze, but also to expose to the influence of sunlight, as well as heating. An opened vial of insulin is strongly recommended to be stored at temperatures from 15 to 25 degrees for 28 days. Provided that the required temperature conditions are observed, the NPH product will be stored for at least three years.
All about drug interactions
Self-completion of treatment or the use of incorrect dosages (especially for patients dependent on insulin) may have an impact on the development of diabetic ketoacidosis or hyperglycemia. As you know, the presented conditions are potentially dangerous for the life of a diabetic. In a certain category of people, when using the human hormonal component, the symptoms of developing hypoglycemia may differ from the signs that are characteristic of the hormonal component of animal origin. Also, they may well have much weaker manifestations.
The transition of a diabetic to other formulations of NPH insulin or their varieties should be carried out exclusively under the supervision of a specialist. Replacing a component with a drug with other indicators of activity by a production method (for example, recombinant DNA, animal) may well require the fastest or, conversely, smooth adjustment of the Humulin NPH dosages used.
With pathological abnormalities in the functioning of the kidneys or liver, insufficient work of the pituitary gland, destabilization of the functioning of the adrenal glands and endocrine gland the need for a hormonal component in a patient can be significantly reduced. With strong psychological stress and other pathological conditions, on the contrary, turn out to be even more significant - there are such changes, according to experts, quite often.
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